Journal article
Exercise early in life in rats born small does not normalize reductions in skeletal muscle PGC-1α in adulthood
RC Laker, ME Wlodek, GD Wadley, LA Gallo, PJ Meikle, GK McConell
American Journal of Physiology Endocrinology and Metabolism | Published : 2012
Abstract
We have previously shown that 4 wk of exercise training early in life normalizes the otherwise greatly reduced pancreatic β-cell mass in adult male rats born small. The aim of the current study was to determine whether a similar normalization in adulthood of reduced skeletal muscle mitochondrial biogenesis markers and alterations in skeletal muscle lipids of growth-restricted male rats occurs following early exercise training. Bilateral uterine vessel ligation performed on day 18 of gestation resulted in Restricted offspring born small (P < 0.05) compared with both sham-operated Controls and a sham-operated Reduced litter group. Offspring remained sedentary or underwent treadmill running fro..
View full abstractGrants
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by University of Melbourne
Funding Acknowledgements
This research was supported by a grant from the National Health and Medical Research Council of Australia (NHMRC; no. 454570) and an Early Career Research Grant from The University of Melbourne (for G.D. Wadley, no. 0606168). R.C. Laker was supported by a Sheppard M. Lowe Scholarship (Faculty of Medicine, Dentistry, and Health Science, The University of Melbourne; 2007) and a cofunded NHMRC/NHF Biomedical Postgraduate Scholarship (2008-2010).